Tag Archives: dna

23andMe Logo

23 and You

23andMe Logo

There has been no shortage of coverage about the FDA dropping the hammer on 23andMe, forcing them to cease distribution of their DNA testing kits (Bloomberg, Business Insider, Forbes, FortuneHacker News, VentureBeat, etc.). Since the initial coverage, the story has continued with 23andMe getting sued in a class action case, and with 23andMe officially becoming a genealogy-only service for new customers (at least temporarily).

Some may be wondering how this intervention by the FDA  affects genetic genealogy? The answer is that directly, it doesn’t affect genetic genealogy at all. This is not an attack at all on genetic genealogy, which is why other DNA testing companies such a Family Tree DNA (FTDNA) and Ancestry have not been similarly contacted by the FDA, even though they use the same, or very similar, testing devices that 23andMe use.

How can the FDA regulate a device being used by 23andMe, but not when it’s used by FTDNA and Ancestry? The answer is that neither FTDNA nor Ancestry use the data collected to provide any health-related information. In fact, I’ve heard FTNDA even does not collect markers used for health analysis, even though they’re available on the chips they use to do their DNA analysis.

Why don’t FTDNA and Ancestry use this data? Well, for one reason, they don’t want the FDA breathing down their necks. In addition, both FTDNA and Ancestry are focused on genetic genealogy. While genetic health information may be of interest to those researching their families, even relevant in many cases to determining if someone is related to you or not, it’s not a critical feature of genetic genealogy.

23andMe, on the other hand, has always been interested in providing analysis of health data found in one’s DNA. Initially, 23andMe offered separate health and genealogy tests. Later they combined everything in one offering. The reason the FDA sent their warning letter to 23andMe, is solely related to the health claims made by 23andMe. How will this effect 23andMe customers? Unless they provide a satisfactory answer to the FDA within the initial 15 day period, which frankly would seem unlikely, they will need to stop sending out genetic testing kits. It’s not clear if they will have to stop providing analysis of health data to existing customers.

Right now, 23andMe has ceased offering health information to new customers – although the FDA could theoretically stop this as well. Presumably they will attempt to come to a deal with the FDA and offer this health information to their new customers in the future. In any case they will be collecting the health markers from new customers and offering them the raw data that they can analyze it themselves.

The real problem would be if 23andMe is prevented from marketing or providing health-related offerings for an extended period of time, and cannot make enough money to remain a going concern. While Ancestry and FTDNA make all their revenues from genealogy-related services, it would certainly appear that 23andMe was heavily focused on the health side of their business. Without the health-related revenue, the company may not be able to keep the doors open. I suspect there is little interest by 23andMe to transition to a genealogy-only company, even if they could do so profitably.

What does this mean to genealogy customers of 23andMe? It means you should be downloading your raw data now, if you haven’t already. Downloading your raw data will allow you to upload the data to another genetic genealogy site in the future. FTDNA, for example, will let you upload 23andMe data to their service for $49. This adds you to their matching database, same as if you had done the Family Finder test through them. They will not keep any of the health-related data, but there are third-party tools that will let you do your own analysis of the data. Some tools are listed by ISOGG (Autosomal DNA Tools), on David Johnson’s site for his 23++ Chrome extension (Getting more from your data), and in Blaine Bettinger’s article What else can I do with my DNA test results? on his The Genetic Genealogist blog. I doubt any of these resources would completely replace the information and analysis that 23andMe provided to its customers, but at least the data won’t go to waste.

On a philosophical level, I think we as individuals deserve the right to access our genetic data without intermediaries. I think the government should take a step back and only intervene in situations where there is clearly fraud being carried out. It is not a coincidence that health insurance companies and organizations that represent doctors have lobbied against direct-to-consumer genetic testing. While most individuals do not have the ability to analyze the data themselves, that’s why 23andMe was developing tools on their site to help in the analysis. I doubt most doctors would be able to provide any analysis of one’s genetic data without similar tools, and if that’s the case, why not allow individuals to see the same information? Of course it’s possible that some individuals, presented with a higher likelihood of developing some horrible medical condition, could freak out and do things detrimental to their health, in most cases this seems unlikely. How many people would have medical procedures carried out without additional targeted testing? What doctor would allow medical intervention without further testing? In short I think 23andMe has the right idea here, but they’ve handled their interaction with the FDA badly. Hopefully they’ll be able to figure out a compromise before the inability to market their health offering affects their ability to continue as a company. That’s where their ability to offer genetic genealogy services could also cease.

I would hope they would transition their database to another company, but considering all the extra privacy steps they have for their health data, it’s likely they would not be able to transfer their entire genealogy database to another company. It’s even possible the company could close up and not offer a way to download your data at that time. That’s why I advocate downloading your raw data now. Personally, if I was at FTDNA, I’d be offering an end-of-the-year deal for $25 to import data from other web sites…

For reference, here’s the statement recently posted on the front page of 23andMe explaining the situation:

Welcome to 23andMe.

At this time, we have suspended our health-related genetic tests to comply with the U.S. Food and Drug Administration’s directive to discontinue new consumer access during our regulatory review process.

We are continuing to provide you with both ancestry-related genetic tests and raw genetic data, without 23andMe’s interpretation.

If you are an existing customer please click the button below and then go to the health page for additional information. If you are a customer who purchased before November 22, 2013, you will still have access to your health-related results.

We remain firmly committed to fulfilling our long-term mission to help people everywhere have access to their own genetic data and have the ability to use that information to improve their lives.

Upon entering the site, please confirm you understand the new changes in our services.

I understand that 23andMe only sells ancestry reports and raw genetic data at this time. I understand 23andMe will not provide health-related reports. However, 23andMe may provide health-related results in the future, dependent upon FDA marketing authorization.

FamilyTree DNA Summer Sale

DNA Inheritance

FamilyTree DNA is having another sale, this one until July 15th which is this coming Sunday. These sales are always a good way to get started in genetic genealogy, or to bring relatives into it. For men, the price of entry is $59, which you can always upgrade later. Oddly the less expensive mtDNA tests for both men and women are not listed in the sale, and in fact I no longer see any option for the cheapest mtDNA test. It seems FTDNA has opted to start mtDNA testing at what was their second tier test, the mtDNAPlus test, which is $159. In many cases, however, women will have more success with a Family Finder autosomal DNA test, which is on sale at $199 (instead of $289) and is probably the better option.

I’ve written before on Using Y-DNA and mtDNA for Genealogy, and I guess I still need to write something more comprehensive about autosomal tests like Family Finder. In short, Family Finder will let you find relatives who are up to your 5th cousins, male or female, as long as they have also been teted. It’s much more of a statistical test than the Y-DNA and mtDNA tests, however, in that if you have a solid match on one of them you can be sure there is a connection on that line, while with Family Finder it’s based on the statistical likelihood and can be thrown off in its estimates if you have cousins who married, etc.

Of note, this the first sale that I’ve noticed the Y-DNA 67-marker test can be upgraded at a discount to the 111-marker test ($109 instead of $129).

Sale prices are listed below. You don’t need any special codes to get the prices, all prices are changed this week when you go to the site. Note that if you were to just go to the site without being a member of a DNA group, the before prices below would in many cases be even higher (Y-DNA 37, for example, is normally $169, $20 more than buying through a group, and Comprehensive is normally $837, is $797 for groups and is $617 during this sale. So go to FamilyTree DNA and buy some kits before Sunday.

Current Group Price
Y-DNA 12
Y-DNA 37
Y-DNA 67
Family Finder
mtFullSequence (FMS)
FF+ Y-DNA 37
FF + mtDNAPlus
Comprehensive (FF + FMS + Y-DNA 67)

12 to 37
25 to 37
25 to 67
37 to 67
37 to 111
67 to 111
mtHVR1 to Mega
mtHVR2 to Mega

So go to FamilyTree DNA now and save some money.

Ancestry.com Launches Autosomal DNA Test

Today Ancestry.com officially launched their autosomal DNA test, which they call simply: AncestryDNA

AncestryDNA user interface

Frankly, I think the name is a bit confusing considering they have other tests for Y-DNA and mtDNA, but that’s a minor point. This new test now competes with FamilyTreeDNA’s Family Finder test and 23andMe’s Relative Finder test. So how does it compare?

The answer, unfortunately, is that I don’t know yet. The only people who have received results so far, considering it just launched today, are those who participated in the beta test, where Ancestry.com sent out tests to various groups of people that were already customers of Ancestry.com. In fact I was one of the people who received a free (not including shipping) kit, but unfortunately there were problems in getting the kit for a long time due to mail problems, so while I have submitted a kit, I haven’t received my results yet.

What I can tell you is what looks good even before I have a chance to look at the DNA results.

For one, I was very grateful they handle something that the other companies haven’t done yet – you can manage the DNA of other people. With 23andMe and FamilyTreeDNA, you essentially set up an account for each person whose DNA is submitted. This doesn’t always make sense. If you’re submitting the DNA of your grandfather who doesn’t use a computer, then you don’t want to have to deal with a separate account, remembering the password, etc. Ancestry.com handles this much better by allowing you to attach DNA kits from multiple people to your existing account.

Another place where Ancestry.com seems to have put in some thought, is connecting tests to people in your family trees. Of course, Ancestry.com has a major advantage here, as they have very sophisticated family trees, that already integrate with other features of their web site such as finding records. The other companies that pioneered autosomal DNA tests do not have family trees of anywhere near the sophistication of what Ancestry.com offers, and thus Ancestry.com holds a clear advantage in this area. You can attach a test, whether the AncestryDNA autosomal test, or one of the existing Y-DNA and mtDNA tests, to a person in your family tree, and presumably Ancestry.com uses that information to try to figure out connections between people who match DNA. How well that works remains to be seen, but it looks promising.

It’s not clear yet whether or not you’ll be able to upload data from another company, or whether you’ll be able to download your data either. Ancestry.com does allow you to download your Y-DNA and mtDNA results, so it makes sense they would allow this for their autosomal test as well, but this test is still in beta and there is no way to download the data as far as I know.

The test is supposed to be priced at $99 with a membership to Ancestry.com. What does that mean? I’m not sure. Is that a price you get once? or if you want to order more tests do you get that price on all tests? What if you’re not an Ancestry.com member? If you only get one kit at $99, does that renew every year when you renew your membership? I’m sure the pricing will be explained better soon.

Anyone else reading this take part in the beta? Did you receive your results? What did you think?

FamilyTree DNA Sale Today and Tomorrow

National DNA Day (April 20, 2012)

Today is National DNA Day, and in honor of this FamilyTreeDNA is having a sale on all its new testing kits, and many of their upgrade kits. If you’ve been holding of getting started with genetic genealogy, or on getting an upgrade on one of your tests, this is your chance to do it a little cheaper. To find out more about how to get started, see my discussion of the topic in an earlier post titled Thinking about trying genetic genealogy?. I also wrote a much more detailed description of Y-DNA (patrilineal) and mtDNA (matrilineal) in my post Using DNA for Genealogy: Y-DNA and mtDNA. For those of you hoping there would be a discount on the Y-DNA 111 test, or the upgrade to it, unfortunately it does not seem to be discounted. No coupons are needed, all the prices are automatically discounted until the end of the day tomorrow.

Discounts in the current sale:

New Kits
Current Group Price SALE PRICE
Y-DNA 12 $99 $59
mtDNA $99 $59
Y-DNA 37 $149 $129
Y-DNA 67 $238 $199
Family Finder $289 $199
mtFullSequence (FMS) $299 $249
Y-DNA 12 + mtDNA $179 $118
FF + Y-DNA 12 $339 $258
FF + mtDNA $339 $258
FF+ Y-DNA 37 $438 $328
FF + mtDNAPlus $438 $328
Comprehensive (FF + FMS + Y-DNA 67) $797 $657
Y-DNA 12 $89 $59
mtDNA add-on $89 $59
Y-DNA 12-37 Marker $99 $69
Y-DNA 37-67 Marker $99 $79
Y-DNA 12-67 Marker $199 $148
mtFullSequence upgrade (HVR1 to Mega) $269 $199
mtFullSequence upgrade (HVR2 to Mega) $269 $199
mtFullSequence add-on $289 $219
Family Finder add-on $289 $199

So check out the sale and get started.

FamilyTreeDNA 2011 Holiday Sale

I’ve discussed genetic genealogy a few times before (in this introduction to a previous sale, and in an article on Y-DNA and mtDNA). If you’ve been interested in trying it out, you can take advantage of FamilyTreeDNA’s Holiday Sale through the end of December. Examples of price reductions include:

Y-DNA37 for $119 instead of $169 ($50 off) – men only
Y-DNA67 for $199 instead of $268 ($69 off) – men only

mtDNAFullSequence for $239 instead of $299 ($60 off) – men and women

FamilyFinder for $199 instead of $289 ($90 off) – men and women

FamilyFinder + Y-DNA37 for $318 instead of $438 ($120 off) – men only
FamilyFinder + mtDNAPlus for $318 instead of $428 ($120 off) – men and women
FamilyFinder + mtDNAFullSequence for $435 instead of $559 ($124 off) – men and women

SuperDNA (Y-DNA67 + mtDNAFullSequence) for $438 instead of $548 ($110 off) – men only
Comprehensive Genome (SuperDNA + FamilyFinder) for $627 instead of $837 ($210 off) – men only

No special coupon is needed. Just go to the Products page and the price reductions should already be shown.

If you’ve successfully used DNA testing to further your genealogy research, post about it in the comments.